{"id":4224,"date":"2026-03-05T11:12:07","date_gmt":"2026-03-05T11:12:07","guid":{"rendered":"https:\/\/nhsdorset.nhs.uk\/medicines\/?page_id=4224"},"modified":"2026-03-06T14:19:04","modified_gmt":"2026-03-06T14:19:04","slug":"dapagliflozin","status":"publish","type":"page","link":"https:\/\/nhsdorset.nhs.uk\/medicines\/value\/dapagliflozin\/","title":{"rendered":"Dapagliflozin"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1310.4px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>The best value preferred sodium-glucose cotransporter-2 inhibitor (SGLT2i).<\/p>\n<\/div><div class=\"accordian fusion-accordian\" style=\"--awb-border-size:1px;--awb-icon-size:18px;--awb-content-font-size:var(--awb-typography4-font-size);--awb-icon-alignment:left;--awb-hover-color:var(--awb-color2);--awb-border-color:var(--awb-color3);--awb-background-color:var(--awb-color1);--awb-divider-color:var(--awb-color3);--awb-divider-hover-color:var(--awb-color3);--awb-icon-color:var(--awb-color5);--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-custom_color_1);--awb-icon-box-color:var(--awb-color5);--awb-toggle-hover-accent-color:var(--awb-color4);--awb-toggle-active-accent-color:var(--awb-color4);--awb-title-font-family:var(--awb-typography1-font-family);--awb-title-font-weight:var(--awb-typography1-font-weight);--awb-title-font-style:var(--awb-typography1-font-style);--awb-title-font-size:20px;--awb-content-font-family:var(--awb-typography4-font-family);--awb-content-font-weight:var(--awb-typography4-font-weight);--awb-content-font-style:var(--awb-typography4-font-style);\"><div class=\"panel-group fusion-toggle-icon-unboxed\" id=\"accordion-4224-1\"><div class=\"fusion-panel panel-default panel-b7753c52cc6617f26 fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-custom_color_1);\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_b7753c52cc6617f26\"><a aria-expanded=\"false\" aria-controls=\"b7753c52cc6617f26\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-4224-1\" data-target=\"#b7753c52cc6617f26\" href=\"#b7753c52cc6617f26\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon fa-capsules fas\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">What work is required?<\/span><\/a><\/h4><\/div><div id=\"b7753c52cc6617f26\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_b7753c52cc6617f26\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><span class=\"TextRun SCXW9465742 BCX8\" lang=\"EN-GB\" xml:lang=\"EN-GB\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW9465742 BCX8\">Dapagliflozin is the best value, preferred SGLT2i in Dorset. In line with <\/span><\/span><span class=\"TextRun Underlined SCXW9465742 BCX8\" lang=\"EN-GB\" xml:lang=\"EN-GB\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW9465742 BCX8\" data-ccp-charstyle=\"Hyperlink\">NHSE recommendations<\/span><\/span><span class=\"TextRun SCXW9465742 BCX8\" lang=\"EN-GB\" xml:lang=\"EN-GB\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW9465742 BCX8\">, PCN teams are asked to ensure that dapagliflozin accounts for 92% of all SGLT2i prescribed in primary care, considering clinical appropriateness.<\/span><\/span><span class=\"EOP SCXW9465742 BCX8\" data-ccp-props=\"\">\u00a0<\/span><\/p>\n<p><strong>Switching is required by the 30th September 2026.<\/strong><\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-cd81d470d22e01383 fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-custom_color_1);\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_cd81d470d22e01383\"><a aria-expanded=\"false\" aria-controls=\"cd81d470d22e01383\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-4224-1\" data-target=\"#cd81d470d22e01383\" href=\"#cd81d470d22e01383\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon fa-capsules fas\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Why is this part of the contract?<\/span><\/a><\/h4><\/div><div id=\"cd81d470d22e01383\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_cd81d470d22e01383\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"12\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Generic dapagliflozin is now available in the UK and is better value than other SGLT2i agents<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"12\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">NICE considers\u202fall SGLT2i to have comparable clinical efficacy and safety profiles.\u00a0<\/span><span data-contrast=\"none\">Adoption of best-value agents allows space for promotion of optimum health outcomes<\/span><span data-contrast=\"none\">\u00a0whilst improving cost-effectiveness across the system<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"12\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Switching to dapagliflozin<\/span><span data-contrast=\"none\">\u00a0<\/span><span data-contrast=\"none\">will help PCN teams care for patients within their NHS England financial envelope and hence, r<\/span><span data-contrast=\"none\">e<\/span><span data-contrast=\"none\">lease funds to improve unmet needs in prevention<\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-96f3246410063abbd fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-custom_color_1);\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_96f3246410063abbd\"><a aria-expanded=\"false\" aria-controls=\"96f3246410063abbd\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-4224-1\" data-target=\"#96f3246410063abbd\" href=\"#96f3246410063abbd\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon fa-capsules fas\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">How do I do it?<\/span><\/a><\/h4><\/div><div id=\"96f3246410063abbd\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_96f3246410063abbd\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><span data-contrast=\"none\">Discuss with local pharmacies, the intention to switch patients to dapagliflozin.<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\"><strong>Run the SystmOne searches provided<\/strong> to identify patients prescribed a SGLT2i other than dapagliflozin:<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<p>Dorset SystmOne GPs>PINH 26 27> 1c Work to do: SGLT2i RPT switch to dapagliflozin<\/p>\n<p><span data-contrast=\"none\">A risk\u00a0<\/span><span data-contrast=\"none\">m<\/span><span data-contrast=\"none\">anagement\u00a0<\/span><span data-contrast=\"none\">a<\/span><span data-contrast=\"none\">pproach should be taken to any batch-switching arrangement, which includes safeguards which enable patients to have a review, should they have any queries or changes to their condition.<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<p><strong>Exclusion criteria:\u00a0<\/strong><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"16\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\"><18 years of age<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"16\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Previous\u00a0intolerance or allergy to dapagliflozin or its excipients<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"16\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Contraindication to dapagliflozin<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"16\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Lack of benefit from prior dapagliflozin use<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"16\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">eGFR < 15 mL\/min\/1.73 m\u00b2<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"16\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Pregnancy and breastfeeding<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/li>\n<\/ul>\n<p><strong>Special considerations:<\/strong><span data-contrast=\"none\">\u00a0<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">When making any change to a medication, please ensure:<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"17\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">any potential drug interactions, cautions and contraindications are considered<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"17\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">all relevant clinical monitoring parameters have been taken in the last 12 months and reviewed: note poorly controlled diabetes<\/span><span data-contrast=\"none\">\u00a0which<\/span><span data-contrast=\"none\"> should be highlighted for review<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"17\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">any necessary dose adjustments have been made: note a lower initiation dose for dapagliflozin is required in severe hepatic impairment and dapagliflozin should be avoided is eGFR < 15ml\/minute\/1.73 m<\/span><span data-contrast=\"none\">2<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"17\" data-list-defn-props=\"{\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">any necessary follow up tests \/ appointments have been booked<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">Where clinically appropriate, after a shared decision-making process with patients, switch patient to dapagliflozin.<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<p><strong>How to communicate this to patients:\u00a0<\/strong><\/p>\n<p><span data-contrast=\"none\">Use the template patient text message and letter in\u00a0SystmOne\u00a0to notify patients of the change. Ensure patient is counselled appropriately.<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-f4e4d5d905fc79988 fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-custom_color_1);\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_f4e4d5d905fc79988\"><a aria-expanded=\"false\" aria-controls=\"f4e4d5d905fc79988\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-4224-1\" data-target=\"#f4e4d5d905fc79988\" href=\"#f4e4d5d905fc79988\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon fa-capsules fas\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">What resources\/support is provided to help me deliver this?<\/span><\/a><\/h4><\/div><div id=\"f4e4d5d905fc79988\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_f4e4d5d905fc79988\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><strong>SystmOne search to identify people potentially eligible for switch:<\/strong><\/p>\n<p>Dorset SystmOne GPs>PINH 26 27> 1c Work to do: SGLT2i RPT switch to dapagliflozin<\/p>\n<p><strong>Patient text message:\u00a0<\/strong><\/p>\n<p><span class=\"TextRun SCXW42129212 BCX8\" lang=\"EN-GB\" xml:lang=\"EN-GB\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW42129212 BCX8\">\"NHS Dorset has asked GP teams to review prescriptions for canagliflozin, empagliflozin or ertugliflozin<\/span><span class=\"NormalTextRun SCXW42129212 BCX8\"> and change to dapagliflozin tablets, which is the NHS England preferred medicine in this class. Dapagliflozin offers the same effect and safety as your current prescription. Please read the label and patient information leaflet before starting this new medication and finish your old supply first. If you have any questions about this change, please ask your Community Pharmacist about a New Medicines Service Review.<\/span><\/span><span class=\"EOP SCXW42129212 BCX8\" data-ccp-props=\"\">\"<\/span><\/p>\n<p><a href=\"https:\/\/nhsdorset.nhs.uk\/medicines\/wp-content\/uploads\/sites\/3\/2026\/02\/Dapagliflozin-template-patient-letter.pdf\">Dapagliflozin template patient letter<\/a><\/p>\n<p><strong>References:\u00a0<\/strong><\/p>\n<p><a href=\"https:\/\/www.dorsetformulary.nhs.uk\/chaptersSubDetails.asp?FormularySectionID=6&SubSectionRef=06.01.02.03&SubSectionID=D100\"><span data-contrast=\"none\">Dorset\u202fFormulary<\/span><\/a><span data-contrast=\"none\">\u202f<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.nice.org.uk\/guidance\/ta390\"><span data-contrast=\"none\">Overview | Canagliflozin, dapagliflozin and empagliflozin as monotherapies for treating type 2 diabetes | Guidance | NICE<\/span><\/a><span data-contrast=\"none\">\u202f<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.nice.org.uk\/guidance\/ta679\"><span data-contrast=\"none\">Overview | Dapagliflozin for treating chronic heart failure with reduced ejection fraction | Guidance | NICE<\/span><\/a><span data-contrast=\"none\">\u202f<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.nice.org.uk\/guidance\/ta902\"><span data-contrast=\"none\">Overview | Dapagliflozin for treating chronic heart failure with preserved or mildly reduced ejection fraction | Guidance | NICE<\/span><\/a><span data-contrast=\"none\">\u202f<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.nice.org.uk\/guidance\/ta1075\"><span data-contrast=\"none\">Overview | Dapagliflozin for treating chronic kidney disease | Guidance | NICE<\/span><\/a><span data-contrast=\"none\">\u202f<\/span><span data-ccp-props=\"\">\u00a0<\/span><\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-145fee8eea5faadfc fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-custom_color_1);\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_145fee8eea5faadfc\"><a aria-expanded=\"false\" aria-controls=\"145fee8eea5faadfc\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-4224-1\" data-target=\"#145fee8eea5faadfc\" href=\"#145fee8eea5faadfc\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon fa-capsules fas\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">How do I calculate my progress against the target for this metric<\/span><\/a><\/h4><\/div><div id=\"145fee8eea5faadfc\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_145fee8eea5faadfc\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>Tracking achievement:<\/p>\n<p>Numerator divided by Denominator from SystmOne searches x 100 for %<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":3067,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-4224","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/nhsdorset.nhs.uk\/medicines\/wp-json\/wp\/v2\/pages\/4224","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhsdorset.nhs.uk\/medicines\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nhsdorset.nhs.uk\/medicines\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nhsdorset.nhs.uk\/medicines\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhsdorset.nhs.uk\/medicines\/wp-json\/wp\/v2\/comments?post=4224"}],"version-history":[{"count":24,"href":"https:\/\/nhsdorset.nhs.uk\/medicines\/wp-json\/wp\/v2\/pages\/4224\/revisions"}],"predecessor-version":[{"id":4476,"href":"https:\/\/nhsdorset.nhs.uk\/medicines\/wp-json\/wp\/v2\/pages\/4224\/revisions\/4476"}],"up":[{"embeddable":true,"href":"https:\/\/nhsdorset.nhs.uk\/medicines\/wp-json\/wp\/v2\/pages\/3067"}],"wp:attachment":[{"href":"https:\/\/nhsdorset.nhs.uk\/medicines\/wp-json\/wp\/v2\/media?parent=4224"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}